 Research has shown that glucose is in part responsible for the cross-linking of proteins, which in turn leads to aging damage. Glucose is found in every cell of the body and is relatively stable, but it can join with protein to form a glucose/ protein combination. It is this combination that will eventually cause cross-linking or glycation. Glucose/ protein substances are constantly cross-linking. This continuous cross-linking may be prevented by using glycation inhibitors like Aminoguanidine. Aminoguanidine is able to stabilise the metabolism of glucose. Therefore it may be able to help alleviate or prevent senile cataracts, thickening of the arteries, kidney failure, thinning bones, osteo-arthritis, skin wrinkles and many other signs of aging associated with the demonstrative effects of glycation. Aminoguanidine has the potential to slow the aging process by protecting the proteins within the human body, such as the skin proteins, eye lens protein, nerve protein and kidney proteins from aging damage. All the body's proteins deteriorate with advancing age and more so in diabetes. Aminoguanidine's ability to stabilize the metabolism of glucose helps prevent and treat adult onset diabetes (Type 2). Aminoguanidine is able to combat some of the adverse effects of diabetes and improve the quality and duration of life. Aminoguanidine also reduces LDL cholesterol (the bad one) and can improve blood flow which in turn helps reverse the conditions of atherosclerosis and blood clots therefore Aminoguanidine offers itself as a true anti-aging medicine especially for the diabetics among us. Dosages and Side Effects In human and animal studies Aminoguanidine has shown to have very low toxicity. Side effects in human trials have been limited to nausea and headache. Aminoguanidine is a fairly new product and data is relatively small therefore dosages should not be exceeded unless under the close supervision of a physician. The usual anti-aging dosage of Aminoguanidine is 150mg to 300mg a day, taken with food. Diabetics may require higher dosages possibly in the range of 300-600mg daily. Aminoguanidine has a half life of only 4-hours, so these dosages would be best split of the course of the day. Glycosylation or cross linking may be responsible for many of the problems in old age. These include senile cataracts, thickening of the arteries, cardiac enlargement, skin aging and damage to the immune system. Aminoguanidine is a anti-glycation inhibitor preventing and possible breaking some protein cross linking. Aminoguanidine protects the proteins which make up the human body. With advancing age all the body’s proteins deteriate. This is especially highlighted in the case of diabetics who have 300% more cross linked proteins compared to non diabetics. It is believed that cross-linking of proteins play a role in the human aging process. Everyone is familiar with the effects of cross-linking reactions, because the process causes food to turn yellow and become tough and it is the result of oxygen coming into contact with glucose and protein. Cross-linking is medically referred to as Glycosylation, and it may be responsible for many of the problems of old age, including; senile cataracts, thickening of the arteries, cardiac enlargement, skin aging, some cancers and damage to the immune system. Aminoguanidine is a potent anti-glycation inhibitor, (it actually inhibits the early stages of glycosylation) and it appears to help prevent some proteins from cross-linking. All the body's proteins deteriorate with advancing age and more so in diabetes (diabetics have 2-3 times the number of cross-linked proteins when compared to non-diabetics and this has lead credence to the fact that diabetes can be viewed as a form of accelerated aging). Animal experiments have shown aminoguanidine can prevent age-related heart enlargement and increase the collagen of arterial walls. Long-term studies conducted in Italy, indicate that aminoguanidine reduces the "bad" form of cholesterol (LDL) in humans and improves blood platelet condition. Recent human and animal studies also indicate that aminoguanidine improves diabetic conditions and improves the survival rates and longevity of animals. It even improves renal (kidney) condition. Aminoguanidine doses are 75mg, 2, 3 or 4 times a day. Aminoguanidine has a half-life of approximately 4-hours, therefore it is preferable to spread the dosage over the day with such a dose-sized tablet. Please note that we supply a hydrochloride (HCL) based tablet. This is more expensive than a bicarbonate based version, but the HCL is more soluble, less irritating and is the type used in the clinical trials. Aminoguanidine has not been shown to date to cause side effects any worse than nausea and headache. But as human clinical trials are still relatively limited, dosages shouldn't be exceeded unless under the supervision of a physician. Aminoguanidine can inhibit the uptake of vitamin B6, so a B6 supplement is recommended whilst using aminoguanidine. Approved Uses | 
